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A map of pericyte ion channels and GPCRs

Hariharan A, Weir N, Robertson C, He L, Betsholtz C, Longden T (2020) "The Ion Channel and GPCR Toolkit of Brain Capillary Pericytes."

Frontiers in Cellular Neuroscience 14:601324. doi: 10.3389/fncel.2020.601324

In collaboration with the Betsholtz group at Uppsala University, this paper systematically explores the ion channels and G protein coupled receptors that are expressed at the mRNA level by brain capillary pericytes, and examines what is currently known of their function, with the aim of providing a roadmap to guide further studies of brain pericyte functions and contributions to blood flow control. In particular, we put forth a model for how pericyte KATP channels may play an critical role in controlling brain blood flow.

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Hariharan A, Weir N, Robertson C, He L, Betsholtz C, Longden T (2020) “The ion channel and GPCR signaling toolkit of CNS pericytesFrontiers in Cellular Neuroscience. 14: 601324.

Garcia D, Longden T (2020) “Ion channels and Ca2+ signaling in the capillary endothelium.” Current Topics in Membranes, 85: 261-300.

Cleary C, Moreira T, Takakura A, Nelson M, Longden T, Mulkey D. (2020) “Vascular control of the CO2/H+-dependent drive to breathe in mice.eLife, 9: e59499.

Mughal A, Sackheim A, Sancho M, Longden T, Russell S, Lockette W, Nelson M, Freeman K. (2020) “Impaired capillary-to-arteriolar electrical signaling after traumatic brain injury.” Journal of Cerebral Blood Flow & Metabolism. In press.

Moshkforoush A, Ashenagar B, Harraz O, Dabertrand F, Longden T, Nelson M, Tsoukias N. (2020) "Capillary Kir channel as sensor and amplifier of neuronal signals: modeling insights on K+-mediated neurovascular communication." Proceedings of the National Academy of Sciences USA. In press.

 

Harraz O, Longden T, Hill-Eubanks D, Nelson M (2018) "PIP2 depletion promotes TRPV4 channel activity in mouse brain capillary endothelial cellseLife. 7: e38689.

 

Harraz O, Longden T, Dabertrand F, Hill-Eubanks D, Nelson M (2018) "Endothelial GqPCR activity controls capillary electrical signaling and brain blood flow through PIP2 depletion"Proceedings of the National Academy of Sciences USA. 115: E3569-E3577.

Tykocki N, Bonev A, Longden T, Heppner T, Nelson M (2017) “Inhibition of vascular smooth muscle inward-rectifier K+ channels restores myogenic tone in mouse urinary bladder arterioles” American Journal of Physiology Renal Physiology, 312(5):F836-F847.

Longden T, Hill-Eubanks D, Nelson M (2016) “Ion Channel Networks in the Control of Cerebral Blood Flow” Journal of Cerebral Blood Flow & Metabolism, 36(3):492-512.

Klitgaard-Povlsen G, Longden T, Bonev A, Hill-Eubanks D, Nelson M (2016) “Uncoupling of Neurovascular Communication After Transient Global Cerebral Ischemia is Caused by Impaired Parenchymal Smooth Muscle KIRChannel Function” Journal of Cerebral Blood Flow & Metabolism, 36(7):1195-1201.

Longden T, Nelson M (2015) “Vascular Inward Rectifier K+ Channels as External K+ Sensors in the Control of Cerebral Blood Flow.” Microcirculation, 22(3): 183-196.

Balbi M, Ghosh M, Longden T, Vega M, Gesierich B, Hellal F, Lourbopoulos A, Nelson M, Plesnila N (2015) “Dysfunction of mouse cerebral arteries during early aging” Journal of Cerebral Blood Flow & Metabolism35(9): 1445-1453.

Villalba N, Sonkusare S, Longden T, Tran T, Sackheim A, Nelson M, Wellman G, Freeman K (2014) “Traumatic brain injury disrupts cerebrovascular tone through endothelial inducible nitric oxide synthase expression and nitric oxide gain of function.” Journal of the American Heart Association, 3(6): e001474.

Longden T, Dabertrand F, Hill-Eubanks D, Hammack S, Nelson M (2014) “Stress-Induced Glucocorticoid Signaling Remodels Neurovascular Coupling Through Impairment of Cerebrovascular Inwardly Rectifying K+Channel Function.” Proceedings of the National Academy of Sciences USA, 111(20): 7462-7.

Longden T, Dunn K, Draheim H, Nelson M, Weston A, Edwards G (2011) “Intermediate-Conductance Calcium-Activated Potassium Channels Participate in Neurovascular Coupling.” British Journal of Pharmacology, 164(3): 922-33.

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